Codon Optimization OnLine (COOL): a web-based multi-objective optimization platform for synthetic gene design

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چکیده

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Codon Optimization OnLine (COOL): a web-based multi-objective optimization platform for synthetic gene design

SUMMARY Codon optimization has been widely used for designing synthetic genes to improve their expression in heterologous host organisms. However, most of the existing codon optimization tools consider a single design criterion and/or implement a rather rigid user interface to yield only one optimal sequence, which may not be the best solution. Hence, we have developed Codon Optimization OnLine...

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 2014

ISSN: 1460-2059,1367-4803

DOI: 10.1093/bioinformatics/btu192